diff --git a/src/sentry/relay/config/__init__.py b/src/sentry/relay/config/__init__.py
index 4ece1fa99200d4..2d95c8e4f89284 100644
--- a/src/sentry/relay/config/__init__.py
+++ b/src/sentry/relay/config/__init__.py
@@ -312,6 +312,23 @@ def _should_extract_abnormal_mechanism(project: Project) -> bool:
     )
 
 
+def _browser_name_one_of(*args):
+    """Returns a condition that matches if an event
+    or span's browser name is one of the options in `args`.
+
+    For events and V1 spans, this checks the `event.contexts.browser.name` field.
+    For V2 spans, it checks the `span.attributes.browser.name.value` field.
+    """
+    return {
+        "op": "or",
+        "inner": [
+            {"op": "eq", "name": field, "value": browser}
+            for field in ["event.contexts.browser.name", "span.attributes.browser.name.value"]
+            for browser in args
+        ],
+    }
+
+
 def _get_desktop_browser_performance_profiles(
     organization: Organization,
 ) -> list[dict[str, Any]]:
@@ -348,11 +365,7 @@ def _get_desktop_browser_performance_profiles(
                     "optional": True,
                 },
             ],
-            "condition": {
-                "op": "eq",
-                "name": "event.contexts.browser.name",
-                "value": "Chrome",
-            },
+            "condition": _browser_name_one_of("Chrome"),
         },
         {
             "name": "Firefox",
@@ -386,11 +399,7 @@ def _get_desktop_browser_performance_profiles(
                     "optional": True,
                 },
             ],
-            "condition": {
-                "op": "eq",
-                "name": "event.contexts.browser.name",
-                "value": "Firefox",
-            },
+            "condition": _browser_name_one_of("Firefox"),
         },
         {
             "name": "Safari",
@@ -424,11 +433,7 @@ def _get_desktop_browser_performance_profiles(
                     "optional": True,
                 },
             ],
-            "condition": {
-                "op": "eq",
-                "name": "event.contexts.browser.name",
-                "value": "Safari",
-            },
+            "condition": _browser_name_one_of("Safari"),
         },
         {
             "name": "Edge",
@@ -462,11 +467,7 @@ def _get_desktop_browser_performance_profiles(
                     "optional": True,
                 },
             ],
-            "condition": {
-                "op": "eq",
-                "name": "event.contexts.browser.name",
-                "value": "Edge",
-            },
+            "condition": _browser_name_one_of("Edge"),
         },
         {
             "name": "Opera",
@@ -500,11 +501,7 @@ def _get_desktop_browser_performance_profiles(
                     "optional": True,
                 },
             ],
-            "condition": {
-                "op": "eq",
-                "name": "event.contexts.browser.name",
-                "value": "Opera",
-            },
+            "condition": _browser_name_one_of("Opera"),
         },
         {
             "name": "Chrome INP",
@@ -517,21 +514,7 @@ def _get_desktop_browser_performance_profiles(
                     "optional": False,
                 },
             ],
-            "condition": {
-                "op": "or",
-                "inner": [
-                    {
-                        "op": "eq",
-                        "name": "event.contexts.browser.name",
-                        "value": "Chrome",
-                    },
-                    {
-                        "op": "eq",
-                        "name": "event.contexts.browser.name",
-                        "value": "Google Chrome",
-                    },
-                ],
-            },
+            "condition": _browser_name_one_of("Chrome", "Google Chrome"),
         },
         {
             "name": "Edge INP",
@@ -544,11 +527,7 @@ def _get_desktop_browser_performance_profiles(
                     "optional": False,
                 },
             ],
-            "condition": {
-                "op": "eq",
-                "name": "event.contexts.browser.name",
-                "value": "Edge",
-            },
+            "condition": _browser_name_one_of("Edge"),
         },
         {
             "name": "Opera INP",
@@ -561,11 +540,7 @@ def _get_desktop_browser_performance_profiles(
                     "optional": False,
                 },
             ],
-            "condition": {
-                "op": "eq",
-                "name": "event.contexts.browser.name",
-                "value": "Opera",
-            },
+            "condition": _browser_name_one_of("Opera"),
         },
     ]
 
@@ -606,11 +581,7 @@ def _get_mobile_browser_performance_profiles(
                     "optional": True,
                 },
             ],
-            "condition": {
-                "op": "eq",
-                "name": "event.contexts.browser.name",
-                "value": "Chrome Mobile",
-            },
+            "condition": _browser_name_one_of("Chrome Mobile"),
         },
         {
             "name": "Firefox Mobile",
@@ -644,11 +615,7 @@ def _get_mobile_browser_performance_profiles(
                     "optional": True,
                 },
             ],
-            "condition": {
-                "op": "eq",
-                "name": "event.contexts.browser.name",
-                "value": "Firefox Mobile",
-            },
+            "condition": _browser_name_one_of("Firefox Mobile"),
         },
         {
             "name": "Safari Mobile",
@@ -682,11 +649,7 @@ def _get_mobile_browser_performance_profiles(
                     "optional": True,
                 },
             ],
-            "condition": {
-                "op": "eq",
-                "name": "event.contexts.browser.name",
-                "value": "Mobile Safari",
-            },
+            "condition": _browser_name_one_of("Mobile Safari"),
         },
         {
             "name": "Edge Mobile",
@@ -720,11 +683,7 @@ def _get_mobile_browser_performance_profiles(
                     "optional": True,
                 },
             ],
-            "condition": {
-                "op": "eq",
-                "name": "event.contexts.browser.name",
-                "value": "Edge Mobile",
-            },
+            "condition": _browser_name_one_of("Edge Mobile"),
         },
         {
             "name": "Opera Mobile",
@@ -758,11 +717,7 @@ def _get_mobile_browser_performance_profiles(
                     "optional": True,
                 },
             ],
-            "condition": {
-                "op": "eq",
-                "name": "event.contexts.browser.name",
-                "value": "Opera Mobile",
-            },
+            "condition": _browser_name_one_of("Opera Mobile"),
         },
         {
             "name": "Chrome Mobile INP",
@@ -775,16 +730,7 @@ def _get_mobile_browser_performance_profiles(
                     "optional": False,
                 },
             ],
-            "condition": {
-                "op": "or",
-                "inner": [
-                    {
-                        "op": "eq",
-                        "name": "event.contexts.browser.name",
-                        "value": "Chrome Mobile",
-                    },
-                ],
-            },
+            "condition": _browser_name_one_of("Chrome Mobile"),
         },
         {
             "name": "Edge Mobile INP",
@@ -797,11 +743,7 @@ def _get_mobile_browser_performance_profiles(
                     "optional": False,
                 },
             ],
-            "condition": {
-                "op": "eq",
-                "name": "event.contexts.browser.name",
-                "value": "Edge Mobile",
-            },
+            "condition": _browser_name_one_of("Edge Mobile"),
         },
         {
             "name": "Opera Mobile INP",
@@ -814,11 +756,7 @@ def _get_mobile_browser_performance_profiles(
                     "optional": False,
                 },
             ],
-            "condition": {
-                "op": "eq",
-                "name": "event.contexts.browser.name",
-                "value": "Opera Mobile",
-            },
+            "condition": _browser_name_one_of("Opera Mobile"),
         },
     ]
 
diff --git a/tests/sentry/relay/snapshots/test_config/test_get_project_config/REGION.pysnap b/tests/sentry/relay/snapshots/test_config/test_get_project_config/REGION.pysnap
index 4c81c60c9a1e35..3e7bd783e6fd1f 100644
--- a/tests/sentry/relay/snapshots/test_config/test_get_project_config/REGION.pysnap
+++ b/tests/sentry/relay/snapshots/test_config/test_get_project_config/REGION.pysnap
@@ -179,9 +179,14 @@ config:
   performanceScore:
     profiles:
     - condition:
-        name: event.contexts.browser.name
-        op: eq
-        value: Chrome
+        inner:
+        - name: event.contexts.browser.name
+          op: eq
+          value: Chrome
+        - name: span.attributes.browser.name.value
+          op: eq
+          value: Chrome
+        op: or
       name: Chrome
       scoreComponents:
       - measurement: fcp
@@ -205,9 +210,14 @@ config:
         p50: 400.0
         weight: 0.1
     - condition:
-        name: event.contexts.browser.name
-        op: eq
-        value: Firefox
+        inner:
+        - name: event.contexts.browser.name
+          op: eq
+          value: Firefox
+        - name: span.attributes.browser.name.value
+          op: eq
+          value: Firefox
+        op: or
       name: Firefox
       scoreComponents:
       - measurement: fcp
@@ -231,9 +241,14 @@ config:
         p50: 400.0
         weight: 0.1
     - condition:
-        name: event.contexts.browser.name
-        op: eq
-        value: Safari
+        inner:
+        - name: event.contexts.browser.name
+          op: eq
+          value: Safari
+        - name: span.attributes.browser.name.value
+          op: eq
+          value: Safari
+        op: or
       name: Safari
       scoreComponents:
       - measurement: fcp
@@ -257,9 +272,14 @@ config:
         p50: 400.0
         weight: 0.1
     - condition:
-        name: event.contexts.browser.name
-        op: eq
-        value: Edge
+        inner:
+        - name: event.contexts.browser.name
+          op: eq
+          value: Edge
+        - name: span.attributes.browser.name.value
+          op: eq
+          value: Edge
+        op: or
       name: Edge
       scoreComponents:
       - measurement: fcp
@@ -283,9 +303,14 @@ config:
         p50: 400.0
         weight: 0.1
     - condition:
-        name: event.contexts.browser.name
-        op: eq
-        value: Opera
+        inner:
+        - name: event.contexts.browser.name
+          op: eq
+          value: Opera
+        - name: span.attributes.browser.name.value
+          op: eq
+          value: Opera
+        op: or
       name: Opera
       scoreComponents:
       - measurement: fcp
@@ -316,6 +341,12 @@ config:
         - name: event.contexts.browser.name
           op: eq
           value: Google Chrome
+        - name: span.attributes.browser.name.value
+          op: eq
+          value: Chrome
+        - name: span.attributes.browser.name.value
+          op: eq
+          value: Google Chrome
         op: or
       name: Chrome INP
       scoreComponents:
@@ -325,9 +356,14 @@ config:
         p50: 500.0
         weight: 1.0
     - condition:
-        name: event.contexts.browser.name
-        op: eq
-        value: Edge
+        inner:
+        - name: event.contexts.browser.name
+          op: eq
+          value: Edge
+        - name: span.attributes.browser.name.value
+          op: eq
+          value: Edge
+        op: or
       name: Edge INP
       scoreComponents:
       - measurement: inp
@@ -336,9 +372,14 @@ config:
         p50: 500.0
         weight: 1.0
     - condition:
-        name: event.contexts.browser.name
-        op: eq
-        value: Opera
+        inner:
+        - name: event.contexts.browser.name
+          op: eq
+          value: Opera
+        - name: span.attributes.browser.name.value
+          op: eq
+          value: Opera
+        op: or
       name: Opera INP
       scoreComponents:
       - measurement: inp
@@ -347,9 +388,14 @@ config:
         p50: 500.0
         weight: 1.0
     - condition:
-        name: event.contexts.browser.name
-        op: eq
-        value: Chrome Mobile
+        inner:
+        - name: event.contexts.browser.name
+          op: eq
+          value: Chrome Mobile
+        - name: span.attributes.browser.name.value
+          op: eq
+          value: Chrome Mobile
+        op: or
       name: Chrome Mobile
       scoreComponents:
       - measurement: fcp
@@ -373,9 +419,14 @@ config:
         p50: 1800.0
         weight: 0.1
     - condition:
-        name: event.contexts.browser.name
-        op: eq
-        value: Firefox Mobile
+        inner:
+        - name: event.contexts.browser.name
+          op: eq
+          value: Firefox Mobile
+        - name: span.attributes.browser.name.value
+          op: eq
+          value: Firefox Mobile
+        op: or
       name: Firefox Mobile
       scoreComponents:
       - measurement: fcp
@@ -399,9 +450,14 @@ config:
         p50: 1800.0
         weight: 0.1
     - condition:
-        name: event.contexts.browser.name
-        op: eq
-        value: Mobile Safari
+        inner:
+        - name: event.contexts.browser.name
+          op: eq
+          value: Mobile Safari
+        - name: span.attributes.browser.name.value
+          op: eq
+          value: Mobile Safari
+        op: or
       name: Safari Mobile
       scoreComponents:
       - measurement: fcp
@@ -425,9 +481,14 @@ config:
         p50: 1800.0
         weight: 0.1
     - condition:
-        name: event.contexts.browser.name
-        op: eq
-        value: Edge Mobile
+        inner:
+        - name: event.contexts.browser.name
+          op: eq
+          value: Edge Mobile
+        - name: span.attributes.browser.name.value
+          op: eq
+          value: Edge Mobile
+        op: or
       name: Edge Mobile
       scoreComponents:
       - measurement: fcp
@@ -451,9 +512,14 @@ config:
         p50: 1800.0
         weight: 0.1
     - condition:
-        name: event.contexts.browser.name
-        op: eq
-        value: Opera Mobile
+        inner:
+        - name: event.contexts.browser.name
+          op: eq
+          value: Opera Mobile
+        - name: span.attributes.browser.name.value
+          op: eq
+          value: Opera Mobile
+        op: or
       name: Opera Mobile
       scoreComponents:
       - measurement: fcp
@@ -481,6 +547,9 @@ config:
         - name: event.contexts.browser.name
           op: eq
           value: Chrome Mobile
+        - name: span.attributes.browser.name.value
+          op: eq
+          value: Chrome Mobile
         op: or
       name: Chrome Mobile INP
       scoreComponents:
@@ -490,9 +559,14 @@ config:
         p50: 500.0
         weight: 1.0
     - condition:
-        name: event.contexts.browser.name
-        op: eq
-        value: Edge Mobile
+        inner:
+        - name: event.contexts.browser.name
+          op: eq
+          value: Edge Mobile
+        - name: span.attributes.browser.name.value
+          op: eq
+          value: Edge Mobile
+        op: or
       name: Edge Mobile INP
       scoreComponents:
       - measurement: inp
@@ -501,9 +575,14 @@ config:
         p50: 500.0
         weight: 1.0
     - condition:
-        name: event.contexts.browser.name
-        op: eq
-        value: Opera Mobile
+        inner:
+        - name: event.contexts.browser.name
+          op: eq
+          value: Opera Mobile
+        - name: span.attributes.browser.name.value
+          op: eq
+          value: Opera Mobile
+        op: or
       name: Opera Mobile INP
       scoreComponents:
       - measurement: inp
diff --git a/tests/sentry/relay/test_config.py b/tests/sentry/relay/test_config.py
index 407a720dfc184f..ea4f60ab0d1753 100644
--- a/tests/sentry/relay/test_config.py
+++ b/tests/sentry/relay/test_config.py
@@ -26,7 +26,6 @@
 from sentry.testutils.factories import Factories
 from sentry.testutils.helpers import Feature
 from sentry.testutils.helpers.datetime import freeze_time
-from sentry.testutils.helpers.options import override_options
 from sentry.testutils.pytest.fixtures import InstaSnapshotter, django_db_all
 from sentry.testutils.silo import cell_silo_test
 from sentry.utils.safe import get_path
@@ -786,9 +785,19 @@ def test_desktop_performance_calculate_score(default_project) -> None:
             },
         ],
         "condition": {
-            "op": "eq",
-            "name": "event.contexts.browser.name",
-            "value": "Chrome",
+            "op": "or",
+            "inner": [
+                {
+                    "op": "eq",
+                    "name": "event.contexts.browser.name",
+                    "value": "Chrome",
+                },
+                {
+                    "op": "eq",
+                    "name": "span.attributes.browser.name.value",
+                    "value": "Chrome",
+                },
+            ],
         },
         "version": "1",
     }
@@ -825,9 +834,19 @@ def test_desktop_performance_calculate_score(default_project) -> None:
             },
         ],
         "condition": {
-            "op": "eq",
-            "name": "event.contexts.browser.name",
-            "value": "Firefox",
+            "op": "or",
+            "inner": [
+                {
+                    "op": "eq",
+                    "name": "event.contexts.browser.name",
+                    "value": "Firefox",
+                },
+                {
+                    "op": "eq",
+                    "name": "span.attributes.browser.name.value",
+                    "value": "Firefox",
+                },
+            ],
         },
         "version": "1",
     }
@@ -864,9 +883,19 @@ def test_desktop_performance_calculate_score(default_project) -> None:
             },
         ],
         "condition": {
-            "op": "eq",
-            "name": "event.contexts.browser.name",
-            "value": "Safari",
+            "op": "or",
+            "inner": [
+                {
+                    "op": "eq",
+                    "name": "event.contexts.browser.name",
+                    "value": "Safari",
+                },
+                {
+                    "op": "eq",
+                    "name": "span.attributes.browser.name.value",
+                    "value": "Safari",
+                },
+            ],
         },
         "version": "1",
     }
@@ -903,9 +932,19 @@ def test_desktop_performance_calculate_score(default_project) -> None:
             },
         ],
         "condition": {
-            "op": "eq",
-            "name": "event.contexts.browser.name",
-            "value": "Edge",
+            "op": "or",
+            "inner": [
+                {
+                    "op": "eq",
+                    "name": "event.contexts.browser.name",
+                    "value": "Edge",
+                },
+                {
+                    "op": "eq",
+                    "name": "span.attributes.browser.name.value",
+                    "value": "Edge",
+                },
+            ],
         },
         "version": "1",
     }
@@ -942,9 +981,19 @@ def test_desktop_performance_calculate_score(default_project) -> None:
             },
         ],
         "condition": {
-            "op": "eq",
-            "name": "event.contexts.browser.name",
-            "value": "Opera",
+            "op": "or",
+            "inner": [
+                {
+                    "op": "eq",
+                    "name": "event.contexts.browser.name",
+                    "value": "Opera",
+                },
+                {
+                    "op": "eq",
+                    "name": "span.attributes.browser.name.value",
+                    "value": "Opera",
+                },
+            ],
         },
         "version": "1",
     }
@@ -973,6 +1022,16 @@ def test_desktop_performance_calculate_score(default_project) -> None:
                     "name": "event.contexts.browser.name",
                     "value": "Google Chrome",
                 },
+                {
+                    "op": "eq",
+                    "name": "span.attributes.browser.name.value",
+                    "value": "Chrome",
+                },
+                {
+                    "op": "eq",
+                    "name": "span.attributes.browser.name.value",
+                    "value": "Google Chrome",
+                },
             ],
         },
         "version": "1",
@@ -990,9 +1049,19 @@ def test_desktop_performance_calculate_score(default_project) -> None:
             },
         ],
         "condition": {
-            "op": "eq",
-            "name": "event.contexts.browser.name",
-            "value": "Edge",
+            "op": "or",
+            "inner": [
+                {
+                    "op": "eq",
+                    "name": "event.contexts.browser.name",
+                    "value": "Edge",
+                },
+                {
+                    "op": "eq",
+                    "name": "span.attributes.browser.name.value",
+                    "value": "Edge",
+                },
+            ],
         },
         "version": "1",
     }
@@ -1009,9 +1078,19 @@ def test_desktop_performance_calculate_score(default_project) -> None:
             },
         ],
         "condition": {
-            "op": "eq",
-            "name": "event.contexts.browser.name",
-            "value": "Opera",
+            "op": "or",
+            "inner": [
+                {
+                    "op": "eq",
+                    "name": "event.contexts.browser.name",
+                    "value": "Opera",
+                },
+                {
+                    "op": "eq",
+                    "name": "span.attributes.browser.name.value",
+                    "value": "Opera",
+                },
+            ],
         },
         "version": "1",
     }
@@ -1061,9 +1140,19 @@ def test_mobile_performance_calculate_score(default_project) -> None:
             },
         ],
         "condition": {
-            "op": "eq",
-            "name": "event.contexts.browser.name",
-            "value": "Chrome Mobile",
+            "op": "or",
+            "inner": [
+                {
+                    "op": "eq",
+                    "name": "event.contexts.browser.name",
+                    "value": "Chrome Mobile",
+                },
+                {
+                    "op": "eq",
+                    "name": "span.attributes.browser.name.value",
+                    "value": "Chrome Mobile",
+                },
+            ],
         },
         "version": "1",
     }
@@ -1100,9 +1189,19 @@ def test_mobile_performance_calculate_score(default_project) -> None:
             },
         ],
         "condition": {
-            "op": "eq",
-            "name": "event.contexts.browser.name",
-            "value": "Firefox Mobile",
+            "op": "or",
+            "inner": [
+                {
+                    "op": "eq",
+                    "name": "event.contexts.browser.name",
+                    "value": "Firefox Mobile",
+                },
+                {
+                    "op": "eq",
+                    "name": "span.attributes.browser.name.value",
+                    "value": "Firefox Mobile",
+                },
+            ],
         },
         "version": "1",
     }
@@ -1139,9 +1238,19 @@ def test_mobile_performance_calculate_score(default_project) -> None:
             },
         ],
         "condition": {
-            "op": "eq",
-            "name": "event.contexts.browser.name",
-            "value": "Mobile Safari",
+            "op": "or",
+            "inner": [
+                {
+                    "op": "eq",
+                    "name": "event.contexts.browser.name",
+                    "value": "Mobile Safari",
+                },
+                {
+                    "op": "eq",
+                    "name": "span.attributes.browser.name.value",
+                    "value": "Mobile Safari",
+                },
+            ],
         },
         "version": "1",
     }
@@ -1178,9 +1287,19 @@ def test_mobile_performance_calculate_score(default_project) -> None:
             },
         ],
         "condition": {
-            "op": "eq",
-            "name": "event.contexts.browser.name",
-            "value": "Edge Mobile",
+            "op": "or",
+            "inner": [
+                {
+                    "op": "eq",
+                    "name": "event.contexts.browser.name",
+                    "value": "Edge Mobile",
+                },
+                {
+                    "op": "eq",
+                    "name": "span.attributes.browser.name.value",
+                    "value": "Edge Mobile",
+                },
+            ],
         },
         "version": "1",
     }
@@ -1218,9 +1337,19 @@ def test_mobile_performance_calculate_score(default_project) -> None:
             },
         ],
         "condition": {
-            "op": "eq",
-            "name": "event.contexts.browser.name",
-            "value": "Opera Mobile",
+            "op": "or",
+            "inner": [
+                {
+                    "op": "eq",
+                    "name": "event.contexts.browser.name",
+                    "value": "Opera Mobile",
+                },
+                {
+                    "op": "eq",
+                    "name": "span.attributes.browser.name.value",
+                    "value": "Opera Mobile",
+                },
+            ],
         },
         "version": "1",
     }
@@ -1243,6 +1372,11 @@ def test_mobile_performance_calculate_score(default_project) -> None:
                     "name": "event.contexts.browser.name",
                     "value": "Chrome Mobile",
                 },
+                {
+                    "op": "eq",
+                    "name": "span.attributes.browser.name.value",
+                    "value": "Chrome Mobile",
+                },
             ],
         },
         "version": "1",
@@ -1259,9 +1393,19 @@ def test_mobile_performance_calculate_score(default_project) -> None:
             },
         ],
         "condition": {
-            "op": "eq",
-            "name": "event.contexts.browser.name",
-            "value": "Edge Mobile",
+            "op": "or",
+            "inner": [
+                {
+                    "op": "eq",
+                    "name": "event.contexts.browser.name",
+                    "value": "Edge Mobile",
+                },
+                {
+                    "op": "eq",
+                    "name": "span.attributes.browser.name.value",
+                    "value": "Edge Mobile",
+                },
+            ],
         },
         "version": "1",
     }
@@ -1277,9 +1421,19 @@ def test_mobile_performance_calculate_score(default_project) -> None:
             }
         ],
         "condition": {
-            "op": "eq",
-            "name": "event.contexts.browser.name",
-            "value": "Opera Mobile",
+            "op": "or",
+            "inner": [
+                {
+                    "op": "eq",
+                    "name": "event.contexts.browser.name",
+                    "value": "Opera Mobile",
+                },
+                {
+                    "op": "eq",
+                    "name": "span.attributes.browser.name.value",
+                    "value": "Opera Mobile",
+                },
+            ],
         },
         "version": "1",
     }