diff --git a/pkg/ctl/topic/set_replication_clusters.go b/pkg/ctl/topic/set_replication_clusters.go
new file mode 100644
index 00000000..f772b10b
--- /dev/null
+++ b/pkg/ctl/topic/set_replication_clusters.go
@@ -0,0 +1,90 @@
+package topic
+
+import (
+	"github.com/apache/pulsar-client-go/pulsaradmin/pkg/utils"
+	"github.com/pkg/errors"
+	"github.com/spf13/cobra"
+	"github.com/spf13/pflag"
+
+	"github.com/streamnative/pulsarctl/pkg/cmdutils"
+)
+
+func SetReplicationClustersCmd(vc *cmdutils.VerbCmd) {
+	desc := cmdutils.LongDescription{}
+	desc.CommandUsedFor = "Set the replication clusters for a topic"
+	desc.CommandPermission = "This command requires tenant admin permissions."
+
+	var examples []cmdutils.Example
+	setReplication := cmdutils.Example{
+		Desc:    "Set the replication clusters for a topic",
+		Command: "pulsarctl topics set-replication-clusters tenant/namespace/topic --clusters cluster1,cluster2",
+	}
+	examples = append(examples, setReplication)
+	desc.CommandExamples = examples
+
+	var out []cmdutils.Output
+	successOut := cmdutils.Output{
+		Desc: "normal output",
+		Out:  "Set the replication clusters for [topic] successfully",
+	}
+
+	noTopicName := cmdutils.Output{
+		Desc: "you must specify a tenant/namespace/topic name, please check if the tenant/namespace/topic name is provided",
+		Out:  "[✖]  the topic name is not specified or the topic name is specified more than one",
+	}
+
+	tenantNotExistError := cmdutils.Output{
+		Desc: "the tenant does not exist",
+		Out:  "[✖]  code: 404 reason: Tenant does not exist",
+	}
+
+	nsNotExistError := cmdutils.Output{
+		Desc: "the namespace does not exist",
+		Out:  "[✖]  code: 404 reason: Namespace (tenant/namespace) does not exist",
+	}
+
+	out = append(out, successOut, noTopicName, tenantNotExistError, nsNotExistError)
+	desc.CommandOutput = out
+
+	vc.SetDescription(
+		"set-replication-clusters",
+		"Set the replication clusters for a topic",
+		desc.ToString(),
+		desc.ExampleToString(),
+		"set-replication-clusters",
+	)
+
+	var clusters []string
+
+	vc.FlagSetGroup.InFlagSet("Set replication clusters", func(flagSet *pflag.FlagSet) {
+		flagSet.StringSliceVarP(&clusters, "clusters", "c", nil,
+			"Replication cluster ids.")
+		_ = cobra.MarkFlagRequired(flagSet, "clusters")
+	})
+	vc.EnableOutputFlagSet()
+
+	vc.SetRunFuncWithNameArg(func() error {
+		return doSetReplicationClusters(vc, clusters)
+	}, "the topic name is not specified or the topic name is specified more than one")
+}
+
+func doSetReplicationClusters(vc *cmdutils.VerbCmd, clusters []string) error {
+	topic := vc.NameArg
+
+	if len(clusters) == 0 {
+		return errors.New("clusters cannot be empty")
+	}
+
+	admin := cmdutils.NewPulsarClient()
+	topicName, err := utils.GetTopicName(topic)
+	if err != nil {
+		return err
+	}
+
+	err = admin.Topics().SetReplicationClusters(*topicName, clusters)
+	if err == nil {
+		vc.Command.Printf("Set the replication clusters successfully on [%s]\n", topic)
+	}
+
+	return err
+}
diff --git a/pkg/ctl/topic/set_replication_clusters_test.go b/pkg/ctl/topic/set_replication_clusters_test.go
new file mode 100644
index 00000000..3a899c4f
--- /dev/null
+++ b/pkg/ctl/topic/set_replication_clusters_test.go
@@ -0,0 +1,31 @@
+package topic
+
+import (
+	"fmt"
+	"testing"
+
+	"github.com/onsi/gomega"
+	"github.com/streamnative/pulsarctl/pkg/test"
+)
+
+func TestSetReplicationClustersCmd(t *testing.T) {
+	g := gomega.NewWithT(t)
+
+	topic := fmt.Sprintf("test-replication-clusters-topic-%s", test.RandomSuffix())
+
+	args := []string{"create", topic, "0"}
+	_, execErr, _, _ := TestTopicCommands(CreateTopicCmd, args)
+	g.Expect(execErr).Should(gomega.BeNil())
+
+	args = []string{"set-replication-clusters", topic, "--clusters", "standalone"}
+	out, execErr, nameErr, cmdErr := TestTopicCommands(SetReplicationClustersCmd, args)
+	g.Expect(execErr).Should(gomega.BeNil())
+	g.Expect(nameErr).Should(gomega.BeNil())
+	g.Expect(cmdErr).Should(gomega.BeNil())
+	g.Expect(out).ShouldNot(gomega.BeNil())
+	g.Expect(out.String()).ShouldNot(gomega.BeEmpty())
+
+	// Since there is no get-replication-clusters command in this PR, we only test the set command success.
+	// In a real scenario, we might want to verify using the client or adding a get command.
+	// The set command output verification implies the call was successful.
+}
diff --git a/pkg/ctl/topic/topic.go b/pkg/ctl/topic/topic.go
index 7d88b159..9dc5cb81 100644
--- a/pkg/ctl/topic/topic.go
+++ b/pkg/ctl/topic/topic.go
@@ -95,6 +95,7 @@ func Command(flagGrouping *cmdutils.FlagGrouping) *cobra.Command {
 		RemoveInactiveTopicCmd,
 		SetDispatchRateCmd,
 		RemoveDispatchRateCmd,
+		SetReplicationClustersCmd,
 	}
 
 	cmdutils.AddVerbCmds(flagGrouping, resourceCmd, commands...)