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Alternate Cell Type Scoring Methods#45

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JacksonLChin wants to merge 2 commits into
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ct_scoring_methods
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Alternate Cell Type Scoring Methods#45
JacksonLChin wants to merge 2 commits into
masterfrom
ct_scoring_methods

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@JacksonLChin
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Implements van Galen and Puram cell type scoring approaches.

 - Adds van Galen cell-type scoring
 - Adjusts RNA-seq import to discard genes with few reads
 - Swaps HAS to use PCA-based scoring to handle missingness
 - Renames alternate cell type scoring to cell_type_scores_vg
 - Adds Puram option to cell_type_scores_vg
 - Adjusts RNA-seq import to remove duplicate genes when converted
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@JacksonLChin JacksonLChin requested a review from dylanhross May 15, 2026 19:07
@JacksonLChin
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@dylanhross This adds the Punam/van Galen scoring approaches. Couple of notes:

  • May be useful to double-check the algorithms here, but I believe they're accurate to the paper.
  • I like to TPM measurements, though they didn't in either paper. There's a kwarg option to enable TPM, but it default to "False" to match previous analysis.

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